Open access
Oct 2026
SLFN11 suppresses PD-L1 through CDK4-mediated BRD4 phosphorylation and ubiquitination by USP10/TRIM21
Pancreatic ductal adenocarcinoma (PDAC) exhibits a dismal prognosis driven by the interplay between dysregulated cell cycle progression in malignant cells and an immunosuppressive tumor microenvironment (TME). Proliferative PDAC subtypes are characterized by heightened immunosuppressive signatures and diminished cy...
Mao-Zhen Peng, Wei Wang, Chao Song et al.
· Cell Death & Disease · 0 citations