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Author

Yue Cheng

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Sep 2026

Angle dependent forced separation and rolling calculations for VWF A1 variants bound to GPIbα.

Binding between the von Willebrand factor (VWF) A1 domain and platelet glycoprotein Ibα (GPIbα) controls platelet capture under flow and changes when disease-associated A1 substitutions alter force-dependent bond lifetimes. We examined how disease-associated A1 substitutions affect bond mechanics under directional load...

Yue Cheng, Zhi-Peng Xu · 0 citations
Aug 2026

R1334 stabilizes the force-bearing von Willebrand factor A1-GPIbα interface.

The VWF A1-GPIbα interaction mediates platelet tethering under flow and exhibits a force-dependent mechanical response. Previous simulations identified R1334 within a multi-residue electrostatic region of the interface, but its specific contribution to equilibrium interfacial stability and tensile resistance has been l...

Yue Cheng, Zhi-Peng Xu · 0 citations

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