Author

Yu-Cheng Guo

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Aug 2026

A Multi-Modal Pre-training Framework-Driven Active Learning System for Enhanced Protein Evolution of Cs CE

Overall, MmALS represents a data-efficient active learning framework for protein evolution, advancing computational enzyme design by enabling accurate optimization under limited experimental sampling.

Chenlu Zhu, Yu-Cheng Guo, Yu-Jie Yang et al. · ACS Catalysis · 0 citations

#protein folding Open access Aug 2026

Modality-chain reasoning enables multimodal protein modelling and design

ProteinReasoner is developed, a multimodal generative protein foundation model that sequentially connects amino acid sequence, evolutionary constraints and three-dimensional structure within a shared autoregressive architecture and suggests a general route towards reasoning across interdependent representations in othe...

Chaozhong Liu, Linlin Chao, Shaomin Ji et al. · bioRxiv · 1 citation