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Author

Yubin Chen

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Open access Sep 2026

ATM inhibition attenuates ferroptosis-associated injury and reduces infarct volume in experimental stroke

Aims: Ferroptosis, an iron-dependent form of regulated cell death, contributes to neuronal injury after ischemic stroke. Because our previous cancer-cell screens identified ataxia-telangiectasia mutated (ATM) kinase, as a ferroptosis regulator, we investigated whether ATM inhibition protects neural tissue after ischemi...

Han Kyu Lee, Chao-Chieh Lin, Denise E. Dunn et al. · 0 citations
#protein folding Open access Aug 2026

The KRASG12C Inhibitor Divarasib Stabilizes RBM39 and Antagonizes Aryl-Sulfonamide Degraders

Using stability-based proteomics, this study shows how protein folding stability-based profiling can expand the actionable target landscape of small molecules beyond canonical covalent interactions, uncovering noncovalent off-targets that may underlie response heterogeneity and treatment-associated toxicity.

Ssu-Yu Chen, Y. Zou, Jianli Wu et al. · 0 citations

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