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Yuanzhen Zhang

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Open access Sep 2026

Single-Cell Analysis Guides Organoid CRISPR Screening to Reveal NF1 as a Gatekeeper of Cervical Squamous Malignant Transformation.

These findings establish NF1 as a critical constraint on HPV-associated epithelial evolution and provide a time-compressed organoid model of cervical carcinogenesis, offering proof-of-concept for therapeutic RAS pathway interception via NF1 restoration.

Bai Hu, Liang Chen, Ren-Jie Wang et al. · 0 citations

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