This review systematically examines the major biological mechanisms underlying relapse after CAR-T therapy in MM, with particular emphasis on both the therapeutic potential of nanotechnology and the translational challenges associated with CAR-T manufacturing optimization, in vivo immune programming, bone marrow microe...
Can Huang, Xu-Yan Zhang, Yuanyin Teng et al.· International Journal of Nan...· 0 citations
It is argued that the field is transitioning from proof-of-principle pharmacodynamic studies toward standardised, biomarker-guided adaptive therapy, and that the principal barriers — technical harmonisation, quantification standards and prospective validation — are now well defined and addressable.
Hao Sun, Xiao-Jun Dong, Jinze Yu et al.· Brazilian Journal of Science· 0 citations
Overall, nanomedicine may support more precise, minimally invasive, and integrated PCa management, but successful translation will require standardized characterization, scalable manufacturing, rigorous safety evaluation, clinically relevant validation, and rational integration with established diagnostic and therapeut...
Jia Wang, Zhong-Song Zhang, Haihao Li et al.· International Journal of Nan...· 0 citations
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