Yuan-Zhen Ma

Host C3 complement restricts bovine coronavirus infection in vitro via virus-induced IL-1β signaling.

Bovine coronavirus (BCoV) is a major enteric and respiratory pathogen of cattle; however, its interactions with the host complement system remain poorly characterized. We previously reported that BCoV modulates host complement C3 expression. Here, we demonstrate that C3 functions as a bona fide cell-intrinsic restricti...