Open access
Sep 2026
The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis
It is reported that the SARS-CoV-2 accessory protein ORF3a binds to the ER chloride channel CLCC1, thereby impairing ER ion homeostasis, activating the unfolded protein response, and inducing endomembrane remodeling.
Liang Guo, Bao-Ying Huang, Han-Zhi Yu et al.
· Cell Discovery · 0 citations