Author

Yuan Wen

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Open access Oct 2026

A Hypertrophic Stimulus Drives Age‐Dependent Transcript Isoform Switching With and Without Differential Gene Expression in Skeletal Muscle

Aged skeletal muscle has a reduced ability to adapt to hypertrophic stimuli concomitant with dysregulation across several molecular layers. Whether altered RNA splicing associates with impaired adaptive potential is not well studied. We hypothesized that aging disrupts the splicing response to involuntary muscle mechan...

Pieter J. Koopmans, Abbey L. Stokes, Christopher E. Nelson et al. · Aging Cell · 0 citations

Open access Aug 2026

Skeletal Muscle Stem Cell-Derived Myonuclei Adopt Divergent Terminal Transcriptional States in Adult and Aged Muscle In Response to a Hypertrophic Stimulus

By defining the age-associated fate of MuSC fusion to muscle fibers, it is provided potential targets for modulating muscle plasticity and predicts Runx1 may function as a master regulator of MuSC-Derived myonuclear specialization in response to MOV.

Nicholas T. Thomas, Jensen Goh, Kevin A. Murach et al. · bioRxiv · 0 citations