Electroacupuncture ameliorates disuse muscular atrophy and inhibits the NLRP3 inflammasome and SIRT1 through miR-133a in a mouse model.
Results indicate that EA-induced reductions of disuse muscular atrophy may be related to miR-133a, and suggest that miR-133a may inhibit NLRP3 inflammasome activation to reduce muscle loss and regulate SIRT1 expression to induce skeletal muscle differentiation and potentially promote muscle tissue recovery.