Covalent Organic Frameworks as Next-Generation Photosensitizers: Mechanistic Underpinnings and Emerging Advances in Antimicrobial Photodynamic Therapy.
Antimicrobial photodynamic therapy (aPDT) offers a non-antibiotic strategy for combating drug-resistant and biofilm-associated infections, but conventional photosensitizers are limited by aggregation, poor targeting, hypoxia, and insufficient biofilm penetration. Covalent organic frameworks (COFs) provide structurally...