Author

Yuan Cui

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Open access Aug 2026

CUDC-907 attenuates pulmonary fibrosis by reversing HDAC1-mediated SMAD4 deacetylation at lysine 45

These findings identify SMAD4 K45 acetylation as a critical molecular switch in fibrogenesis and position CUDC-907 as a promising epigenetic strategy for the treatment of fibrotic lung diseases.

Yu Li, Yuan Cui, Hao-Yu Qiu et al. · Biology Direct · 0 citations

Aug 2026

TWIST2-dependent transcriptional activation of TPI1 mediates TGF-β1-driven fibroblast activation in pulmonary fibrosis.

The TGF-β1/TWIST2/TPI1 signaling axis is defined as an important regulator of pathogenic fibroblast behavior and pro-fibrotic responses through transcriptional control of TPI1, highlighting its potential as a therapeutic target for IPF.

Jiawei Chen, Yu Li, Kai Fu et al. · Cellular Signalling · 0 citations