Review
Open access
Oct 2026
The sirtuin family: from mechanisms to therapy
Sirtuins (SIRT1–SIRT7) are evolutionarily conserved NAD+-dependent deacylases that function as metabolic sensors, coupling cellular metabolic state to epigenetic, transcriptional and post-translational regulatory programs across distinct subcellular compartments. Despite two decades of research, isoform- and disease-sp...
Jia-Ying Xiao, Yi-Ling Li, Yu-Yao Xie et al.
· Molecular Biomedicine · 0 citations