Methylnissolin preserves chondrocyte homeostasis and attenuates experimental osteoarthritis through modulation of the PI3K-AKT-NF-κB signaling axis.
BACKGROUND Osteoarthritis (OA) involves extracellular matrix (ECM) degradation, inflammation, oxidative stress, mitochondrial dysfunction, and chondrocyte loss. Methylnissolin (MN) is a natural isoflavonoid with anti-inflammatory and antioxidant properties, but its effects in OA remain unclear. PURPOSE To evaluate th...