Yu Zhang

Spatial multi-omics reveals OAT-associated arginine-proline metabolic remodeling in Paraquat-induced Parkinsonian and depression-like phenotypes.

Paraquat (PQ) is a highly toxic bipyridyl herbicide that remains in agricultural use in some regions despite bans or severe restrictions elsewhere and is also widely used as a model toxicant for investigating environmentally induced neurodegeneration. However, the spatial metabolic alterations associated with PQ-induce...