Author

Yu-Xin Li

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Open access Sep 2026

Chikungunya Virus E2 N218K Enhances Heparan Sulfate-Dependent Attachment and Viral Internalization While Conferring Partial Attenuation in A129 Mice

Findings identify N218K as a determinant of HS-dependent attachment and partial attenuation in A129 mice, reveal a “high attachment–low dissemination” phenotype, and show that this charge-altering E2 substitution enhances post-attachment internalization.

Teng Chen, Jie Zhang, Zhe-Rui Zhang et al. · Pathogens · 0 citations

Open access Oct 2026

A single residue in the Gc protein dictates neutralization sensitivity and virulence in SFTSV.

Severe fever with thrombocytopenia syndrome virus (SFTSV), a World Health Organization (WHO) priority pathogen, causes hemorrhagic fever with up to 30% case fatality and lacks approved vaccines or therapeutics. Here, we isolated Gc-specific monoclonal antibodies H2, H4, and H12. H2 potently neutralized endemic Chinese...

Xiao-Yu Zhang, Xue-Kai Zhang, Pei-Pei Yang et al. · Cell Reports · 0 citations