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Review Open access Sep 2026

Prolonged molecular control during intermittent reduced‐intensity blinatumomab maintenance in a transplant‐ineligible patient with Philadelphia chromosome‐positive acute lymphoblastic leukaemia and IKZF1 deletion

Abstract Objectives Long‐term disease control in transplant‐ineligible patients with high‐risk Philadelphia chromosome‐positive acute lymphoblastic leukaemia (Ph+ ALL) remains difficult, particularly when adverse genetic lesions and acquired kinase domain mutations coexist. Methods Clinical, cytogenetic and molecular r...

Xiao-Qian Duan, Jin-Jun Yang, Yu-Fei Yang et al. · 0 citations
Sep 2026

Targeting ClpP Rewires the Metabolic-Immune Axis in Acute Myeloid Leukemia.

Acute myeloid leukemia (AML) critically depends on oxidative phosphorylation (OXPHOS). Mitochondrial targeted therapies are advancing into clinical trials, but metabolic vulnerabilities have been primarily explored from a tumor-intrinsic perspective. Leukemic cells can actively reshape an immunosuppressive tumor microe...

Xin-Rong Xiang, Bao-Zhu Luo, Lei Zhao et al. · 0 citations
Aug 2026

Mutant p53 reactivation and DNA demethylation in the treatment of AML/MDS.

It is reported that mutant p53 rescued by ATO treatment strengthened interferon responses triggered by the DNA hypomethylating agent decitabine by transactivating interferon regulatory factor 7 (IRF7) directly.

Huaxin Song, Xin-Jie Chen, Shujun Xiao et al. · 1 citation

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