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Sep 2026
Abstract Objectives Long‐term disease control in transplant‐ineligible patients with high‐risk Philadelphia chromosome‐positive acute lymphoblastic leukaemia (Ph+ ALL) remains difficult, particularly when adverse genetic lesions and acquired kinase domain mutations coexist. Methods Clinical, cytogenetic and molecular r...
Xiao-Qian Duan, Jin-Jun Yang, Yu-Fei Yang et al.
· Clinical & Translational Imm... · 0 citations
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Sep 2026
Acute myeloid leukemia (AML) critically depends on oxidative phosphorylation (OXPHOS). Mitochondrial targeted therapies are advancing into clinical trials, but metabolic vulnerabilities have been primarily explored from a tumor-intrinsic perspective. Leukemic cells can actively reshape an immunosuppressive tumor microe...
Xin-Rong Xiang, Bao-Zhu Luo, Lei Zhao et al.
· Cancer Research · 0 citations
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Aug 2026
It is reported that mutant p53 rescued by ATO treatment strengthened interferon responses triggered by the DNA hypomethylating agent decitabine by transactivating interferon regulatory factor 7 (IRF7) directly.
Huaxin Song, Xin-Jie Chen, Shujun Xiao et al.
· Science Translational Medici... · 1 citation
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