miR-133a deficiency is associated with cardiac and skeletal muscle remodeling and enhanced Fosl-2/TGF-β1/Smad3-related profibrotic signaling in ischemic heart failure
Exercise intolerance in heart failure (HF) reflects combined cardiac and skeletal muscle abnormalities, but the molecular associations underlying concurrent remodeling remain unclear. We examined cardiac and skeletal muscle phenotypes in a rat model of ischemic HF with global miR-133a deficiency and explored cand...