Exosomal METTL16 from mesenchymal stem cells promotes malignant progression and M2 macrophage polarization in acute myeloid leukemia via IGF2BP2-dependent GPX1 m6A modification.
BACKGROUND Acute myeloid leukemia (AML) progression relies on complex crosstalk with the bone marrow microenvironment, particularly M2 macrophage polarization. Exosomes mediate intercellular communication, while N6-methyladenosine (m6A) modifications drive tumor malignancy. However, the role of exosomal m6A regulators...