Sep 2026
Mucoadhesive recombinant human catalase for dry eye disease: From protein engineering to first-in-human study.
BACKGROUND Oxidative stress caused by excess reactive oxygen species (ROS) plays a key role in the progression of dry eye disease (DED), yet no approved DED therapy directly eliminates ROS. Here, we develop an antioxidant biologic with enhanced ocular-surface retention by thiol engineering of recombinant human catalase...
Ming Shao, Yi-Teng Lu, Wen-Jie Xie et al.
· i Medicina · 0 citations