Oct 2026
Loss of Tars induces proteostasis stress and drives HSPC exhaustion through mTORC1 activation.
Ning-Zhe Li, Meng-Ke He, Qiang Wang et al.
· Acta Pharmacologica Sinica · 0 citations
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Aug 2026
Mutant p53 reactivation and DNA demethylation in the treatment of AML/MDS.
It is reported that mutant p53 rescued by ATO treatment strengthened interferon responses triggered by the DNA hypomethylating agent decitabine by transactivating interferon regulatory factor 7 (IRF7) directly.
Huaxin Song, Xin-Jie Chen, Shujun Xiao et al.
· Science Translational Medici... · 1 citation