Robust Biomolecular Complex Design Across Protein Conformational Landscapes
FlexEvo is introduced, a model-agnostic evolutionary framework that adapts candidates once at inference time from a single target conformation to improve compatibility with alternative natural conformations unseen during adaptation, without retraining the source model or requiring a conformational ensemble.
Qing-Yuan Zeng, Zong-Qi Xu, Ang-Lin Liu et al.
· 0 citations