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Review Open access Sep 2026

BMAL1 in cardiovascular diseases: Molecular mechanisms, circadian regulation and translational perspectives (Review)

Current evidence does not support viewing BMAL1 as simply protective or harmful, and small-molecule clock modulators, chronotherapy and non-pharmacological interventions, as well as time-resolved multi-omics and machine-learning approaches are assessed.

Yu Liang, Ting-Jin Chen, Xue-Mei Wen et al. · 0 citations
Open access Jul 2026

Platelet membrane biomimetic nanoparticle-based targeted delivery system of simvastatin for the treatment of ischemic stroke

Blood–brain barrier (BBB) disruption and excessive neuroinflammation are pivotal drivers of cerebral ischemia-reperfusion injury. Although simvastatin (SV) possesses potent pleiotropic effects in promoting BBB repair and attenuating inflammation, its clinical translation for ischemic stroke is severely hampered by poor...

Qin Li, Rong-Yuan Li, Lu Lin et al. · 0 citations

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