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Review Open access Oct 2026

Multimodal biomarkers for early detection and immunotherapy assessment in hepatocellular carcinoma: integrating liquid biopsy, AI-based imaging and tumor immune profiling

Hepatocellular carcinoma (HCC) commonly develops in chronically diseased liver and remains challenging because of late detection, heterogeneity, recurrence and limited hepatic reserve. Immune checkpoint inhibitor (ICI)-based combinations improve outcomes in advanced HCC, but durable responses occur in only a subset of...

Yu-Li Zhao, Xiao-Lei Chen, Han-Yuan Zhao · 0 citations
Open access Jul 2026

Metabolic-immunoregulatory subtypes reveal prognostic and therapeutic insights in multiple primary lung cancer

Background Multiple primary lung cancer (MPLC) is an increasingly recognized subtype characterized by distinct lesions with independent origins. While recent studies have profiled the immune landscape of MPLC, its tumor-intrinsic metabolic features and immunoregulatory interactions remain largely unexplored. Methods Si...

Yuli Zhao, Hanyu Zhao, Hui-Sheng Wu et al. · 0 citations

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