UBA6 confers neuroprotection against sepsis-associated encephalopathy through facilitating LCN2 ubiquitin-dependent degradation.
Sepsis-associated encephalopathy (SAE) is a common secondary complication of sepsis, accompanied by neuroinflammation and neuronal apoptosis. As an E1 ubiquitin-activating enzyme, ubiquitin-like modifier-activating enzyme 6 (UBA6) deficiency aggravates inflammation. Herein, we first confirmed that UBA6 is decreased in...