Sep 2026
Dual sensing activates antiviral reverse transcriptase for membrane targeting.
The prokaryotic type 2 defense-associated reverse transcriptase (DRT2) system mediates antiviral defense by catalyzing the rolling-circle reverse transcription of a noncoding RNA (ncRNA) and producing the toxic Neo protein that arrests bacterial growth. However, the mechanisms underlying DRT2 activation and effector fu...
Yu-Shan Xia, Hua Qi, Xin-Yang Wei et al.
· Cell Host and Microbe · 0 citations