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Yu-Jin Chen

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Open access Sep 2026

Structure-based design of subtype-selective psychedelic analogs

Classical psychedelics exert hallucinogenic and therapeutic effects primarily through activation of serotonin 2 A receptor (5-HT2AR), offering promise as transformative treatments for neuropsychiatric disorders. However, their concurrent activation of 5-HT2BR—associated with cardiac valvulopathy—raises serious safety c...

Hui-Qiong Li, Lingjie Tang, Jin-Feng Zhang et al. · 0 citations

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