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Yu-Jie Gan

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Review Open access Sep 2026

Dysfunction of CD58 in tumor immune evasion: from mechanistic regulation to therapeutic resistance

CD58, the primary ligand of the co-stimulatory receptor CD2, plays a crucial role in the formation of the immunological synapse (IS) and the initiation of antitumor immunity involving T cells and natural killer (NK) cells. Aberrant CD58 expression, resulting from genomic inactivation, epigenetic silencing, transcript...

Peng-Fei Guo, Ming Yi, Yu-Jie Gan et al. · 0 citations

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