Author

Yu-Jiao Liu

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Review Open access Sep 2026

Lactylation Remodels Tumorigenesis, Immune Microenvironment, and Therapeutic Response

This review systematically summarizes the molecular mechanisms and enzymatic basis of lactylation, as well as its regulatory functions in core cancer hallmarks and the immune microenvironment, evaluates the translational prospects of targeting the lactate–lactylation axis, and discusses the key scientific questions and...

Yu-Fei Liu, Yu-Tong Zhou, Hui-Wen Xue et al. · Current Issues in Molecular... · 0 citations

Review Aug 2026

Targeted protein degradation: mechanistic diversity, therapeutic expansion, and clinical translation.

This review provides a roadmap for translating TPD into transformative therapies and outlines key challenges including novel E3 ligase ligand discovery, tissue selectivity, and acquired resistance, and discusses how covalent fragment screening, artificial intelligence, and expanded E3 ligase repertoires will advance ne...

Caiyu Wang, Zhibin Guo, Yu-Fei Liu et al. · International journal of pha... · 0 citations