Ferroptosis in Pancreatic Ductal Adenocarcinoma: Mechanisms, Tumor Biology, and Therapeutic Opportunities.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal human malignancies, characterized by persistently poor survival rates and limited effective therapeutic options. Ferroptosis, an iron-dependent form of regulated cell death driven by uncontrolled lipid peroxidation, has recently emerged as a potenti...