Author

Yu Hu

2 papers indexed here

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Open access Sep 2026

Kidney fibrosis is mediated by GARP-restricted TGF-β activation in fibroblasts.

GARP-mediated release of active TGF-β is identified as a critical step in sustaining fibroblast activation during kidney fibrosis and highlight GARP as a promising therapeutic target for CKD.

Yin-Tong Chen, Wei-Wei Xu, Jie-Li Yu et al. · JCI Insight · 0 citations

Open access Aug 2026

Integrated single-cell and spatial transcriptomic analyses identify a unique subset of pro-fibrotic macrophage in kidney fibrosis.

INTRODUCTION Acute kidney injury (AKI) is a severe clinical syndrome associated with high morbidity and mortality, and it possesses high risk of progression to chronic kidney disease (CKD). Renal infiltration of inflammatory cells, particularly macrophages, plays a key role in driving the progression from AKI to CKD....

Liuyan Xiao, Yinyi Long, Xue Hong et al. · Journal of Advanced Research · 0 citations