Gut microbiota-derived indole-3-acetic acid ameliorates necrotizing enterocolitis-induced adolescent-stage cognitive impairment via regulating AHR-mediated neuroinflammation and synaptic structural integrity.
BACKGROUND Necrotizing enterocolitis (NEC) is the most severe acute gastrointestinal disease in preterm infants and is an independent risk factor for adolescent-stage cognitive deficits, especially persistent cognitive impairment. Accumulating evidence indicates that gut-brain axis dysfunction mediates NEC-related brai...