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Review Open access Sep 2026

From Monovalent EV-A71 Vaccines to Multivalent Vaccines Against Hand, Foot and Mouth Disease in China: Development Progress, Evidence Gaps, and Translational Challenges

Hand, foot and mouth disease (HFMD) is caused by several enteroviruses, with enterovirus A71 (EV-A71) most strongly associated with severe disease and death. Licensed monovalent inactivated EV-A71 vaccines in China have a substantial evidence base for safety, immunogenicity, protective efficacy, and real-world effectiv...

Yi Zhang, Yu Gu, Zhi Li et al. · 0 citations

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