BACKGROUND
Excessive unnecessary protein accumulation in cardiomyocyte is a leading contributor for pathological cardiac hypertrophy and has been found closely regulated by the mTORC1 (mechanistic target of rapamycin complex 1) signaling and lysosome transmembrane proteins. However, the precise regulatory mechanism str...
Yu-Feng Hu, Wei Li, Man-Li Hu et al.· Circulation· 0 citations
BACKGROUND
Myocardial ischemia-reperfusion (MIR) injury compromises therapeutic effects of revascularization and leads to functional impairment and exacerbation of structural damage in the heart. Limiting the damage caused by MIR is crucial but is still an unmet clinical need because of the complexity of the underlying...
Si-Yi Zhou, Jia-Yi Liu, Man-Li Hu et al.· Circulation· 0 citations
Cardiovascular diseases (CVDs) remain a leading cause of death worldwide, with a complex and multifactorial pathophysiology. Given its high energy demands, the heart is critically dependent on mitochondrial energy production and metabolic homeostasis. Mitophagy, a selective form of autophagy, represents a crucial intra...
Deyi Guo, Kun Wang, Jingwen Zhang et al.· Journal of Cardiology· 0 citations
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