Open access
Oct 2026
The R2TP Complex Couples mTORC1 Signaling to Vacuolar ATPase Assembly and Lysosomal Function
The vacuolar ATPase (V‐ATPase) is essential for lysosomal acidification and autophagy, and its activity is regulated by nutrient‐sensitive reversible assembly of its V1 and Vo domains. While mTORC1 is known to inhibit V‐ATPase assembly, the precise molecular mechanisms remain incompletely understood. Here, using TurboI...
Xiao-Wen Zhang, Ming-Yue Wu, Qi Zhu et al.
· Journal of Cellular Biochemi... · 0 citations