Yu-Bo Tang

Profilin promotes lamellipodium protrusion by tuning the antagonistic activities of capping protein and VASP

Cell migration frequently employs protrusions termed lamellipodia, constituting the prime model system for generation of branched actin filament networks. Here we utilize genome editing to explore the functional connections between the actin monomer-binding protein profilin (Pfn), the filament nucleating Arp2/3 complex...