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Youyuan Li

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Open access Aug 2026

ETfinder: harnessing conserved C-terminal tails of single-stranded DNA-binding proteins for mining and engineering RecET systems in non-model microbial chassis

ETfinder is presented, a framework that uses the conserved C-terminal tail of host single-stranded DNA-binding proteins (SSB-Ct) as a biochemical constraint to guide the discovery of RecET recombineering systems and prioritizes high-compatibility homologs, reduces experimental screening burden, and expands the accessib...

Dongyuan Lv, Mindong Liang, Yiyang Gu et al. · 0 citations
Open access Aug 2026

TRACER navigates rearrangement-driven sesterterpene chemical space via multimodal enzyme-product representation learning

TRACER (terpene rearrangement annotation via co-attentive enzyme-product representation), a multimodal framework mapping the latent associations between sequence-derived enzyme representations and product chemotypes, establishes a predictive paradigm for the rational discovery and mechanistic elucidation of complex ter...

Cuiping Xing, Kangjie Lv, Wei-Yan Zhang et al. · 0 citations

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