Open access
Sep 2026
Pharmacological modulation of GPR84 revealed by dual states structures and immune functional assays
G-protein-coupled receptor 84 (GPR84) is an orphan class A GPCR selectively activated by medium chain fatty acids and highly expressed in immune cells, where it modulates pro-inflammatory signaling. The structural basis of GPR84 inactivation and antagonism has remained unclear, limiting the rational design of pathway-s...
Myung Kyung Choi, D. Park, Pankyung Kim et al.
· Experimental and Molecular M... · 0 citations