Open access
Nov 2026
Efficient and accurate mixed model association tool for single-cell eQTL analysis.
Genetic effects on gene expression often vary across cell types, motivating expression quantitative trait loci (eQTL) mapping in single-cell RNA sequencing data. Existing approaches generally aggregate expression across cells, use Gaussian models poorly suited to read counts or do not scale. Here we show that SAIGE-QTL...
Wei Zhou, Anna S. E. Cuomo, Lin-Feng Hu et al.
· Nature Genetics · 0 citations