Vibriosis causes substantial losses in marine and brackish-water aquaculture, while increasing antimicrobial resistance limits the effectiveness of conventional antibiotic treatment. Biofilm formation and quorum-sensing-controlled virulence further contribute to the persistence of pathogenic Vibrio species. Prophages i...
Nazia Tabassum, A. Javaid, Abirami Karthikeyan et al.· Antibiotics· 0 citations
This review examines the molecular architecture and domain organization of Als3, including the N-terminal peptide-binding cavity (PBC) and the amyloid-forming region, as well as the regulatory network controlling ALS3 expression, which is one of the few targets for which a single treatment can act on both the fungal an...
A. Javaid, Nazia Tabassum, Y. M. Siddiqui et al.· Critical reviews in microbio...· 0 citations
The structure and regulatory circuitry of PrfA are addressed, then antivirulence strategies targeting this protein using natural compounds, synthetic inhibitors, and nanomaterial-based approaches are surveyed.
Nazia Tabassum, A. Javaid, Abirami Karthikeyan et al.· Molecular Biology Reports· 0 citations
This review highlights SpoVG’s function in Staphylococcus, including its regulation of the expression of the adhesion factor gene sasC and the thermonuclease, which enables SpoVG to act as a molecular rheostat that influences biofilm formation and reduces acute virulence in response to environmental signals.
Abirami Karthikeyan, A. Javaid, G. N. A. Charway et al.· World Journal of Microbiolog...· 0 citations
Molecular docking results provided a molecular basis for the conjugate's interaction with target proteins (PDB IDs: 4LFU and 4TQX), suggesting its potential as a quorum-sensing modulator.
In vivo experiments reveal that the hydrogel significantly accelerated wound closure via improved re-epithelialization, collagen production, and neovascularization and modulated macrophage polarization toward M2 phenotype in full-thickness wound model in streptozotocin (STZ)-induced diabetic mice, suggesting this photo...
D. Park, Se-Chang Kim, Geum-Jae Jeong et al.· International Journal of Bio...· 0 citations
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