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Author

Young Ah Goo

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Open access Sep 2026

Structural mechanisms for ATP-mediated inhibition of human NLRP6 inflammasome.

Cryogenic-electron microscopy structures of human NLRP6 monomer in the adenosine-5'-triphosphate (ATP)/NBD-bound (twisted conformation) and unbound (extended conformation) states reveal the ATP-mediated cooperative inhibition mechanism of NLRP6 and provide insight into the therapeutic intervention of NLRP6-related auto...

Zhen Cui, Qi Sheng, Minsoo Son et al. · 0 citations

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