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You-Yu Lan

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Open access Sep 2026

Single-cell profiling reveals context-dependent immune regulation shared by sepsis and systemic lupus erythematosus

SIGLEC1 and TRIM25 are context-dependent immune signatures in sepsis and SLE, with loss-of-function evidence supporting SIGLEC1 in macrophage inflammatory responses, and both genes exhibited potential discriminatory capacity between disease cohorts and healthy controls.

Yan Xu, Hao Wang, Ying-Chun Hu et al. · 0 citations

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