Dopamine receptors (DRs) mediate central and peripheral dopaminergic signaling and remain major therapeutic targets in movement disorders, psychiatric disease, and endocrine dysfunction. Despite decades of clinical use, existing DR-directed therapies still suffer from limited subtype selectivity, pathway-nonspecific en...
You-Wen Zhuang, H. E. Xu· Annual Review of Pharmacolog...· 0 citations
Protein–protein interactions (PPIs) are central to biological processes, making the identification of both interacting partners and their binding sites important for understanding molecular function and guiding therapeutic discovery. However, connecting large-scale partner prediction to residue-level interaction eviden...
He Yang, Ru-Xin Lei, You-Wen Zhuang et al.· bioRxiv· 0 citations
G protein-coupled receptors (GPCRs) signal across a continuum of activation states, yet how ligands encode distinct signaling efficacies remains poorly understood. Here, we define the molecular mechanism underlying graded activation of the dopamine D1 receptor (D1R), a major therapeutic target for neuropsychiatric diso...
Xinyue Zhang, Yu Zheng, Heng Liu et al.· bioRxiv· 0 citations
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