Oct 2026
Unipoint-anchored cascade amplification strategy integrating FUSE probe-activated CRISPR-Cas12a for dual mode osteopontin detection toward osteosarcoma assessment and therapeutic response evaluation.
Reliable assessment of disease status and therapeutic response in osteosarcoma remains an unmet clinical need. Integrative bioinformatics analysis and protein-level verification in paired clinical specimens prioritized secreted phosphoprotein 1 (SPP1, osteopontin) as a liquid biopsy target associated with osteosarcoma...
Jie Zhao, Miao-Miao Gao, Hong-Mei Ding et al.
· Biosensors & bioelectronics · 0 citations