Yosuke Togashi

Liver-specific amino acid metabolism impacts on efficacy of cancer immunotherapy.

The combination immunotherapies, including those with atezolizumab and bevacizumab (Atez/Bev), have become standard therapy for hepatocellular carcinoma (HCC). However, its efficacy remains limited and reliable biomarkers are lacking. In this study, we analyzed paired tumor and background liver tissues from Atez/Bev-tr...

Clinical perspectives on mitochondria in cancer.

Modalities to identify clinically actionable neoantigens.

Recent experimental platforms have been developed to validate neoantigen immunogenicity, which can be complemented by single-cell RNA/T-cell receptor sequencing to identify tumor-reactive T cell clones.