Magnesium Attenuates Renal Senescence and Fibrosis With Reduced DNA Damage Response and H3K4me3 Enrichment at the p16INK4a Promoter
Renal fibrosis is a final pathway leading to end‐stage renal disease, with cellular senescence contributing to fibrosis and inflammation. Magnesium ions (Mg2+) are implicated in DNA stabilization and epigenetic regulation. In this study, we hypothesized that Mg2+ ameliorates renal fibrosis in association with reduced D...