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Author

Yoshinori Hiraoka

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Open access Aug 2026

Nardilysin fine-tunes the mammalian circadian clock through selective modulation of PER2 function

Circadian rhythms in mammals are generated by negative feedback loops, in which CLOCK and BMAL1 bind to E-box to activate transcription of Period (Per) and Cryptochrome (Cry) and the E-box-dependent transactivation is inhibited by PER and CRY proteins. Although the core transcriptional feedback loop of the circadian cl...

Yoshinori Hiraoka, R. Nunokawa, Mikiko Ohno et al. · 0 citations
Sep 2026

Identification of a small-molecule inhibitor of nardilysin and its pharmacological effects on transcriptional regulation and inflammatory arthritis.

Nardilysin (NRDC) is a zinc metallopeptidase of the M16 family that participates in diverse biological processes, including ectodomain shedding and antigen processing. NRDC also functions as a transcriptional coregulator, and this coregulatory activity depends on its metallopeptidase catalytic function. However, small-...

Yasutaka Amano, Kiyoto Nishi, Hazuki Sano et al. · 0 citations

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