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Author

Yoshiaki Tanaka

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Open access Sep 2026

ESRRB: from embryonic development to cancer

ESRRB is an essential orphan nuclear receptor in embryonic development and in the maintenance of pluripotency. It can contribute to the self-renewal capacity of embryonic stem cells by regulating gene networks involved in cell fate decisions, influenced by core transcription factors such as NANOG, SOX2 and OCT4. Mech...

Emma Rocaboy, Shiva Ghadiri, Yoshiaki Tanaka · 0 citations
Open access Sep 2026

Elucidating the role of DEAF1 in neurodevelopment and shared molecular pathways in high-risk autism genes using cortical organoids

This work shows that a DEAF1 mutation in human embryonic stem cells disrupts chromatin accessibility at neuronal gene loci, leading to significant transcriptional alterations, and identifies WNT signaling, TGFβ superfamily signaling, and cell cycle regulation as commonly dysregulated pathways across multiple ASD-associ...

Jonghun Kim, Museog Choe, W. Yang et al. · 1 citation

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