Author

Yoon-Jin Lee

2 papers indexed here

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Open access Aug 2026

ABRL8301, a Novel 2-Methoxyestradiol Derivative, Mitigates Progressive Pulmonary Fibrosis by Downregulating 11β-Hydroxysteroid Dehydrogenase 1.

Progressive pulmonary fibrosis (PPF) is a severe lung disease characterized by persistent tissue damage and scarring, with no curative therapies currently available. The multifactorial and poorly understood pathogenesis complicates drug development, highlighting the need for novel multi-targeted anti-fibrotic therapeut...

So-Won Heo, Junghwan Choi, Yeonhwa Song et al. · European Journal of Pharmaco... · 0 citations

Open access Sep 2026

HIF-1α-ASS1 axis drives reprogramming of arginine metabolism controls hepatic stellate cell activation in hepatic fibrosis.

Dysregulated arginine metabolism promotes hepatic stellate cell (HSC) activation and liver fibrosis. However, the mechanisms underlying arginine hosmeostasis in hepatic fibrogenesis and therapeutic targeting remain unclear. Using Multicellular hepatic spheroid (MCHS) models recapitulating in vivo liver fibrosis, we inv...

Seungeun Lee, Yeonhwa Song, Sanghwa Kim et al. · Phytomedicine · 0 citations