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Yongyan Tang

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Open access 2026

Dual-dynamic control and metabolic rebalancing guided by toxic target discovery for efficient dencichine production

A growth-phase-dependent dual-dynamic regulation circuit is developed that gradually activates serA expression and progressively represses serB expression as cells enter the stationary phase, thereby reducing 2-HG accumulation and alleviating L-serine auxotrophy.

Yu Zhang, Jun Wu, Jinghua Yu et al. · 0 citations

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